1. Ruff KJ, Morrison D, Duncan SA, Back M, Aydogan C and Theodosakis J. Beneficial Effects of NEM® Brand Eggshell Membrane Versus Placebo in Exercise-induced Joint Pain, Stiffness & Cartilage Turnover in Healthy, Post-menopausal Women. Clinical Interventions in Aging, 2018:13 285-295.
2. Ruff KJ, DeVore DP, Leu MD and Robinson MA. (2009) Eggshell Membrane: A Possible New Natural Therapeutic For Joint & Connective Tissue Disorders. Results From Two Open-label Human Clinical Studies. Clinical Interventions in Aging, 4:235-240.
3. Ruff KJ, Winkler A, Jackson RW, DeVore DP and Ritz BW. (2009) Eggshell Membrane in the Treatment of Pain and Stiffness from Osteoarthritis of the Knee: A Randomized, Multicenter, Double Blind, Placebo Controlled Clinical Study. Clinical Rheumatology, 28:907-914.
4. Danesch U, Seybold M, Rittinghausen R, Treibel W and Bitterlich N. (2014) NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. Journal of Arthritis, 3(3):136.
5. Brunello E and Masini A. (2016) NEM® Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Associated with Osteoarthritis of the Knee in an Italian Study Population. Interna-tional Journal of Clinical Medicine, 7:169-175.
6. Benson KF, Ruff KJ and Jensen GS. (2012) Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion. Journal of Medicinal Food, 15(4):360-368.
7. Ruff KJ and DeVore DP. (2014) Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Modern Research in Inflammation, 3(1):19-25.
8. Sim BY, Bak JW, Lee HJ, Jun JA, Choi HJ, Kwon CJ, Kim HY, Ruff KJ, Brandt K and Kim DH. (2015) Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. Journal of Nutrition and Health, 48(4):310-318.
9. Wedekind KJ, Ruff KJ, Atwell CA, Evans JL and Bendele AM. (2016). Beneficial Effects of Natural Eggshell Membrane (NEM) on Multiple Indices of Arthritis in Collagen-Induced Arthritic Rats. Mod-ern Rheumatology, 1-38.
10. Ruff KJ, Kopp KJ, Von Behrens P, Lux M, Mahn M and Back M. (2016) Effectiveness of NEM® brand eggshell membrane in the treatment of suboptimal joint function in dogs: a multicenter, randomized, double-blind, placebo-controlled study. Veterinary Medicine: Research & Reports, 7:113-121.
11. Ruff KJ, Durham PL, O’Reilly A and Long FD. (2015) Eggshell membrane hydrolyzates activate NF-kB in vitro: possible implications for in vivo efficacy. Journal of Inflammation Research, 8:49-57.
12. Eskiyurt N, Saridogan M, Senel K, Gunaydin R, Erdal A, Akarirmak U, Sendur F, Barut K, Akyüz G, Ozsoy T, Tuncer T, Karatas O, Irdesel J, Ketenci A and Aydogan C. (2016) AB0762 Efficacy and Safety of Nem®-Stratum Nutrition's Brand Eggshell Membrane in Patients with Knee Os-teoarthritis Accompanying with Joint Pain and Stiffness. A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Crossover Study (under review).
** Kanadische Gesundheitbehörde: Health Canada